- Oct 1 William Hepworth Thompson, English classical scholar and Master of Trinity College, Cambridge, dies at 76
- Oct 8 Austin F. Pike, American politician from New Hampshire (b. 1819)
- Oct 10 David L Yule, 1st Jewish US senator, dies
- Oct 18 Philipp Franz von Siebold, German physician (b. 1796)
- Oct 21 Jose Hernandez, Argentine poet (La vuelta the MartinFierro), dies at 51
- Oct 23 Johann Nepomuk Kafka, composer, dies at 67