Florence Cathedral
Apr 24 Michelangelo undertakes to carve 12 Apostles for the Cathedral of Florence, each four and a quarter braccia high (248.2cm), at the rate of at least one completed statue per year. He produced only one, of St. Matthew, and that remained unfinished.
- Apr 28 Battle at Cerignalo: Spanish army under Gonzalo Fernández de Córdoba defeats a French force led by Louis d'Armagnac, Duke of Nemours