- Jan 20 Christian II succeeds Johan I as Danish and Norwegian king
Historic Expedition
Mar 27 Spaniard Juan Ponce de León and his expedition first sight Florida
Juan Ponce de León
- Apr 2 Explorer Juan Ponce de León claims Florida for Spain as the first known European to reach Florida
- Jun 6 Battle of Novara, the War of the League of Cambrai: the Swiss Confederacy defeat the French
Victory in Battle
Aug 16 Battle of the Spurs at Guinegate (now Eguinegatte): Henry VIII of England and Holy Roman Emperor Maximilian I beat France
Henry VIII
- Sep 9 Battle of Flodden Fields; English defeat James IV of Scotland
- Sep 23 King Henry III & Emperor Maximilian conquer Doornik
- Sep 25 Spanish explorer Vasco Nunez de Balboa crosses the Panama Isthmus becoming first European to see the Pacific Ocean
- Oct 7 Battle of La Motta: Spanish troops under Ramón de Cardona defeat the Venetians.