- Feb 8 Heavy storm strikes Dutch coast, many die
- Feb 27 Saxony and Hesse form League of Gotha (league of Protestant princes)
- Mar 15 French Dauphin Francis and his brother Henry exchanged as hostages for their father Francis I, beginning four years of captivity in Spain under Treaty of Madrid
- Mar 17 French King Francis I freed from Spain
- Mar 26 King Francis I returns from Spanish captivity to France
First Battle of Panipat
Apr 21 First Battle of Panipat: Central Asian conqueror Babur defeats Sultan Ibrahim Lodi, establishing the Mughal Empire in India
- Apr 22 1st slave revolt in North America at San Miguel de Gualdape, a Spanish settlement (now part of South Carolina)
- May 2 German evangelical monarchy joins Schmalkaldic League
- May 22 Pope Clemens VII, France, Genoa, Venice, Florence & Milan form Anti-French League of Cognac
- May 26 Four remaining ships of the Spanish Laoisa Expedition sail into the Pacific Ocean, soon be separated in a storm, only one will successfully cross to reach the Spice Islands)
- Jun 25 Diet of Speyer convenes, resulting in the Edict of Speyer, which temporarily suspends the 1521 Edict of Worms (a Papal ban on Luther's teachings); allows Lutheranism and other "reforms" to propagate unimpeded throughout Germany
Victory in Battle
Aug 29 Battle of Mohács: In a decisive battle the Hungarian Empire is conquered by the Ottoman Empire led by Suleiman the Magnificent
