- May 3 Strategic city of Santa Cruz de Mompox founded on the Magdalena River (modern Colombia) by Spanish conquistadors
Victory in Battle
Jul 12 Battle of Albancay: Diego de Almagro defeated by army led by Alonso de Alvarado on behalf of Francisco Pizarro
Historic Publication
Sep 2 Danish King Christian III publishes "Ordinance on the Danish Church" establishing Lutheranism as the state religion within his realms
- Sep 24 Catholic uprising in the Free and Hanseatic City of Lübeck (now Germany) fails
- Oct 4 1st printing in England of complete English-language Bible, the "Matthew's Bible", with translations by William Tyndale and Miles Coverdale (an update of the earlier "Coverdale Bible") [exact month/day unclear] [1]