- Feb 9 The first recorded race meet in England (Roodee Fields, Chester)
Seven Cities of Gold
Feb 23 Francisco Vázquez de Coronado's expedition sets off from Mexico in search of the 7 cities of Cibola
Hernando de Soto's Expedition lands in Florida
Jun 3 Spanish conquistador Hernando de Soto crosses the Appalachian Mountains, 1st European to do so
Event of Interest
Jun 10 Thomas Cromwell arrested in Westminster
Event of Interest
Jun 24 English King Henry VIII commands his 4th wife, Anne of Cleves, to leave the court
- Jun 29 Former Lord Privy Seal and Chancellor of the Exchequer of England Thomas Cromwell indicted as a heretic
- Jul 23 Turkey recognizes John Sigismund Zápolya as vassal king of Hungary
- Aug 15 Arequipa is founded in Peru
- Aug 25 Explorer Hernando de Alarcon travels up Colorado River
- Aug 29 Emperor Karel deprives city Gent of its definitive rights and privileges
- Sep 27 Pope Paul III officially recognizes the Society of Jesus (Jesuit) co-founded by Ignatius of Loyola as a religious order of the Catholic church
- Oct 2 Venice and Turkey signs peace
- Oct 11 Emperor Karel names his son Philip, Duke of Milan