- Apr 29 Flemish woman introduces practice of starching linen into England
- Jun 12 King Edward VI accepts Archbishop Cranmer's "42 Articles"
Aug 13 Spanish theologian and physician Michael Servetus arrested as a heretic in Geneva (put on trial the next day, eventually found guilty of heresy and burned to death)
- Aug 23 Bishop Stephen Gardiner appointed English Lord Chancellor
- Sep 13 English bishop Hugh Latimer arrested
- Oct 21 Volumes of Talmud are burned
- Oct 27 Condemned as a heretic, Michael Servetus is burned at the stake just outside Geneva
- Nov 13 English Lady Jane Grey and Archbishop Thomas Cranmer accused of high treason
- Dec 25 Battle of Tucapel: Mapuche rebels under Lautaro defeats the Spanish conquistadors and exetutes the governor of Chile Pedro de Valdivia.