- Mar 7 Christian fleet under Gian Andrea lands at Djerba, North Africa
- Mar 13 Spanish fleet occupies Djerba, at Tripoli
- Mar 15 Failed assault on royal palace in Amboise, France
Execution
Apr 13 Giovanni, son of Italian mathematician Girolamo Cardano is executed for poisoning his wife, despite his father's efforts to save him

Girolamo Cardano
Event of Interest
Aug 21 Tycho Brahe becomes interested in astronomy

Tycho Brahe
Appointment of Interest
Sep 25 Spanish King Philip II names Frederik Schenck of Toutenburg as 1st archbishop of Utrecht

Philip II of Spain