- Jan 7 2nd Bank of US opens in Philadelphia, Pennsylvania
Event of Interest
Jan 18 José de San Martín leads a revolutionary army over the Andes to attack Spanish royalists in Chile

José de San Martín
- Jan 22 British freighter Diana sinks off Malaya
Music Premiere
Jan 25 Gioachino Rossini's opera "La Cenerentola" (Cinderella) premieres in Rome

Gioachino Rossini
- Jan 31 Franz Grillparzer's "Die Ahnfrau" premieres in Vienna
- Feb 5 1st US gas co incorporated, Baltimore (coal gas for street lights)
- Feb 7 Baltimore becomes the 1st American city lit by gas street lamps with the first turned on at Market and Lemon Streets (currently Baltimore and Holliday Streets)
- Mar 2 1st Evangelical church building dedicated, New Berlin, Pennsylvania
- Mar 3 Mississippi Territory is divided into Alabama Territory & Mississippi
President Inaugurated
Mar 4 James Monroe is inaugurated as the 5th President of the United States

James Monroe
- Mar 8 The New York Stock Exchange is founded
- Mar 25 Tsar Alexander I recommends formation of Society of Israeli Christians
- Apr 15 1st American school for the deaf opens (Hartford, Connecticut)
- Apr 17 1st US school for deaf (Hartford, Connecticut)
- Apr 22 Curacao prohibits use of white paint due to fierce sunlight
- May 15 Ambonese uprising against Dutch authority (modern Indonesia), under Thomas Matulesia (aka Kapitan Pattimura)
- May 15 First private mental health hospital opens in the US, Asylum for the Relief of Persons Deprived of the Use of Their Reason (now Friends Hospital) in Philadelphia, Pennsylvania
- May 16 Mississippi River steamboat service begins
- Jun 8 An uprising involving three hundred workers in the English town of Pentrich begins but is quashed almost immediately
- Jul 4 Chief Engineer James Geddes begins construction on the Erie Canal, (Rome, New York), one of the first great engineering works in North America
- Jul 12 1st flower show held in Dannybrook, County Cork, Ireland
- Jul 12 Karl Drais von Sauerbronn demonstrates bicycle course
- Aug 18 60-70ft sea serpent sightings reported offshore in Gloucester, Massachusetts
- Sep 9 Alexander Twilight, probably first African American to graduate from a US college, receives BA degree at Middlebury College
Event of Interest
Sep 22 John Quincy Adams becomes US Secretary of State

John Quincy Adams
- Oct 9 University of Gent officially opens
- Oct 20 1st Mississippi "Showboat" leaves Nashville on maiden voyage
- Nov 20 First Seminole War begins in Florida
- Nov 25 First sword swallower in US performs (NYC)
- Nov 27 US soldiers attack Florida Indian village, beginning Seminole War
- Dec 10 Mississippi admitted as 20th state of the Union
- Dec 16 Leaders of Molukkas uprising hanged in Ambon