- Sep 1 Two suicide bombings kill 12 people and wound 50 in a NATO base in Afghanistan's Sayed Abad district
- Sep 1 US drone strike kills 5 people in North Waristan, Pakistan
- Sep 1 Islamist rebels seize Douentza, Mali
- Sep 1 Grenade injures 41 festival celebrants in Paquibato, Philippines
- Sep 2 15 people are killed by a car bomb attack at a refugee camp in Sbeineh, Palestine
- Sep 2 A decades-long ban on veiled female news presenters is lifted from State television in Egypt
- Sep 3 New Zealand announces withdrawal of its forces from Afghanistan
- Sep 3 3 people are killed and 19 wounded by a car bombing in Peshawar, Pakistan
- Sep 3 Typhoon Bolaven kills 48 people in North Korea
- Sep 4 25 people are killed at a funeral suicide bombing in Nangarhar, Pakistan
- Sep 4 42 people are killed and 25 injured as a passenger bus falls down a ravine in Morocco
- Sep 4 Pauline Marois becomes the first female premier of Quebec
- Sep 4 Carpet that can help prevent falls among the elderly by warning them of unusual footsteps is developed
- Sep 5 54 people are killed and 50 injured after a firecracker factory explodes in Nadu
- Sep 5 Austerity measure requires Greece to increase its maximum working days to six per week
- Sep 5 25 are killed and 4 wounded after an ammunition store exploded in Afyon, Turkey
- Sep 6 61 illegal immigrants die after a fishing boat capsizes off the coast of Turkey
Presidential Convention
Sep 6 Barack Obama accepts the Democratic nomination for US President
Video Music Awards
Sep 6 29th MTV Video Music Awards: Rihanna f/ Calvin Harris, Nicki Minaj & Chris Brown win
- Sep 7 US drone attack kills 8 people in Kismayo, south Somalia
- Sep 7 64 people are killed and 715 injured after a series of earthquakes in south-west China
- Sep 7 Canada closes its Iranian embassy and expels Iranian diplomatic staff out of Canada
- Sep 8 6 people are killed by a Taliban suicide bombing in Kabul, Afghanistan
- Sep 8 8 people are killed after a tractor is hit by a train in Romania
- Sep 9 17 people are killed and at least 40 injured after two car bombs explode in Aleppo, Syria
- Sep 9 100 people are killed and 350 injured after a wave of attacks across Iraq
- Sep 9 Armenia wins the 40th FIDE Chess Olympiad
US Open Women's Tennis
Sep 9 US Open Women's Tennis: Serena Williams wins her 4th US title; beats Victoria Azarenka of Belarus 6-2, 2-6, 7-5
- Sep 10 16 people are killed by a suicide bombing in Kunduz, Afghanistan
- Sep 10 Teachers in Chicago strike effecting 350,000 students
- Sep 10 10,000 miners demonstrate at Lonmin mines in Marikana, South Africa
- Sep 10 29 people are killed by floods and heavy rain in Vietnam
- Sep 10 A left over bazooka grenade in Cambodia explodes and kills three children
US Men's Tennis Open
Sep 10 US Open Men's Tennis: Andy Murray of Scotland wins his first Grand Slam event; beats defending champion Novak Đoković 7-6, 7-5, 2-6, 3-6, 6-2
- Sep 11 50 Al-Shabaab fighters are killed in conflict with the Somali National Army
- Sep 11 The US consulate in Benghazi, Libya, is stormed, looted and burned down, killing five people, including the US ambassador
- Sep 11 The US is warned by Moody's that its AAA credit rating is at risk if lawmakers fail to produce a long-term debt reduction plan
- Sep 11 29 people are killed and 11 injured after a bus runs off a mountain highway in Nepal
- Sep 11 Japan nationalizes three of the disputed Senkaku Islands
- Sep 12 18 soldiers are killed by a rebel car bomb in Syria
- Sep 12 314 people are killed in factory fire in Karachi and Lahore, Pakistan
- Sep 12 Apple unveils its iPhone 5 and iOS 6
Historic Event
Sep 12 Excavators announce that they may have found the remains of King Richard III of England under a carpark in Leicester
Historic Event
Sep 13 Russian Prime Minister Dmitry Medvedev calls for Russian punk band Pussy Riot to be freed
- Sep 13 Dr Mustafa Abushagur is elected as Prime Minister of Libya
- Sep 14 21 people are killed after a ferry sank in Indonesia
- Sep 15 Japan announces that it will phase out nuclear energy by the 2030s
- Sep 16 8 female civilians are killed by a NATO airstrike in Laghman, Afghanistan
- Sep 16 8 police officers are killed by a roadside bombing by Kurdistan Workers' Party militants in Turkey
- Sep 16 14 people are killed and 7 wounded by a roadside bomb Jandol, Turkey
- Sep 16 Anti-Japanese protesters set fire to Panasonic plant in Qingdao, China
- Sep 16 Mayor of Chicago, Rahm Emanuel, seeks a court order to resolve a week long teachers strike
- Sep 16 NHL locks out its players after the expiry of the collective bargaining agreement
- Sep 16 37th Toronto International Film Festival: "Silver Linings Playbook" directed by David O. Russell wins the People's Choice Award
- Sep 16 British Open Women's Golf, Royal Liverpool GC: Jiyai Shin wins her second Open title, 9 strokes ahead of fellow South Korean Inbee Park
- Sep 17 Panasonic suspends operations at its three factories in China
- Sep 17 China dispatches 1,000 fishing boats to Senkaku Islands
- Sep 17 13 people are killed in a bus accident in Jubail, Saudi Arabia
Historic Event
Sep 17 Swedish forensic scientists find no conclusive evidence of Wikileaks founder Julian Assange's DNA in a torn condom
- Sep 17 United States and Japanese government officials agree to put a second missile defence system in Japan
- Sep 18 10 Turkish soldiers are killed and 70 injured in missile attack by Kurdish militants in Bingol, Turkey
- Sep 18 26 people are killed in a fire in a Pemex gas facility in Reynosa, Mexico
- Sep 18 The Chicago Teachers Union and Chicago Public Schools reach a deal that ends an 8-day strike.
- Sep 18 World's first mother-to-daughter uterus transplant undertaken at the University of Gothenburg
- Sep 19 9 people are killed and 20 wounded by a car bombing in Peshawar, Afghanistan
- Sep 20 50 people are killed and dozens injured after a gas station is bombed by the Syrian Army in Ain Issa
- Sep 20 14 people are killed in a cafe suicide bombing in Somalia
- Sep 20 AU Optronics fined $500 million for a LCD screen price-fixing
- Sep 21 Japanese Prime Minister, Yoshihiko Noda, wins a leadership ballot
- Sep 22 7 pedestrians are killed by a drunk driver who hit a bus stop at 200km an hour in Moscow
Farm Aid Concert
Sep 22 Farm Aid held in Hershey, Pennsylvania; performers include Willie Nelson, John Mellencamp, Neil Young, Dave Matthews, Kenny Chesney, Jack Johnson, Grace Potter & the Nocturnals, Dale Watson, and Pegi Young
Emmy Awards
Sep 23 64th Emmy Awards: "Homeland", "Modern Family", Damian Lewis & Claire Danes win
- Sep 24 Books by Japanese authors or about Japan are suspended by Chinese bookstores
- Sep 25 50 Taiwanese ships clash with the Japan Coast Guard in waters off the Senkaku Islands
- Sep 25 Anouchka van Miltenburg is elected President of the House of Representatives in the Netherlands
- Sep 26 Syrian army massacres 40 civilians in Thiabieh, Damascus
- Sep 26 Greek trade unions call a general strike to protest austerity measures
- Sep 26 Japanese automakers suspend operations in China
- Sep 27 UN publicly releases documents from China and Japan detailing their contesting claims for the Senkoku Islands
- Sep 27 The Mars Curiosity rover discovers what evidence of a fast-moving streambed-in Mars
- Sep 27 The 2004 Japanese discovery of the 133th element has been confirmed
- Sep 28 Aircraft crash kills 16 people in Kathmandu, Nepal
- Sep 28 Nigeria suspends flights to Saudi Arabia after hundreds of Nigerian women travelled without a male escort
- Sep 30 Two opposition Venezuelan politicians are shot dead a week before the presidential election
- Sep 30 Car bomb blasts kill at least 32 people across Iraq
- Sep 30 Melbourne Storm defeat the Canterbury Bulldogs in the 2012 NRL Grand Final
- Sep 30 Ryder Cup Golf, Medinah CC: Europe retains Cup 14½-13½; win 8 and tie 1 of the 12 singles matches after trailing 10-6