- Sep 3 Nick Wechsler, American actor (Roswell), born in Albuquerque, New Mexico
- Sep 4 Wes Bentley, American actor, born in Jonesboro, Arkansas
- Sep 5 Laura Bertram, Canadian actress (Trance Gemini-Andromeda), born in Toronto, Ontario
- Sep 6 Natalia Cigliuti, Uruguayan-American actress (Lindsay-Saved By Bell: New Class), born in Montevideo, Uruguay
- Sep 6 Mathew Horne, English actor (Gavin & Stacey), born in Nottingham, England
- Sep 11 Ben Lee, Australian musician and actor (The Rage in Placid Lake), born in Sydney, Australia
- Sep 12 Elisabetta Canalis, Italian model and actress, born in Sassari, Italy
- Sep 12 Ben McKenzie, American actor (Gotham), born in Austin, Texas
- Sep 12 Ruben Studdard, American singer (American Idol, I Need An Angel), born in Frankfurt, Germany
- Sep 13 Megan Henning, American actress (I Know Who Killed Me), born in Baltimore, Maryland
- Sep 14 Carmen Kass, Estonian model (estimated to have been the second-highest-paid model in the world in 2002), born in Talinn, Estonia
- Sep 16 Matthew Rogers, American TV host and country singer, born in Arcadia, California
- Sep 16 Nick Cordero, Canadian Broadway actor (Bullets Over Broadway), born in Hamilton, Canada (d. 2020)
- Sep 18 Shelly Moore, Miss Teen USA (Tennessee, 1997), born in Jacksonville, Florida
- Sep 18 Pilar López de Ayala, Spanish actress (Juana la Loca), born in Madrid, Spain
- Sep 19 Michelle Alves, Brazilian supermodel, born in Londrina, Paraná, Brazil
- Sep 19 Nigel Mitchell, English TV presenter (Quizmania and Capital Disney), born in Kingston Upon Thames, England
- Sep 23 Worm Miller, American filmmaker
- Sep 23 Keri Lynn Pratt, American actress
- Sep 25 Jodie Kidd, English model, born in Guildford, United Kingdom
- Sep 28 Marzena Godecki, actress (Ocean Girl)
- Sep 30 Candice Michelle, American female wrestler
About September 1978
How Old? 42 years old
Generation: Generation X
Leap Year: No