- Mar 20 Princess Cecily of York (d. 1507)
Guru Nanak (1469-1539)
Apr 15 Founder of the religion of Sikhism and the 1st Sikh Guru, born in Rai-Bhoi-Di-Talwandi, Punjab, Pakistan
Niccolo Machiavelli (1469-1527)
May 3 Italian statesman and author (The Prince), born in Florence, Italy
- May 19 Giovanni della Robbia, Italian Renaissance sculptor (d. 1529)
- May 31 Manuel I, King of Portugal (1495-1521) during era of exploration known as "Manuel The Fortunate", born in Alcochete, Portugal (d. 1521)
- Oct 9 John Fisher, British Catholic clergyman (Bishop of Rochester, 1504-35; Cardinal, 1535), martyr, and saint who was beheaded [birthdate disputed], born in Beverley, England (d. 1535)