- Jan 10 Margaret of Austria, Regent of the Netherlands, born in City of Brussels, Belgium (d. 1530)
Ferdinand Magellan (1480-1521)
Feb 3 Portuguese explorer, born in Trás-os-Montes e Alto Douro, Portugal
- Feb 13 Girolamo Aleandro, Italian Catholic cardinal, Treviso, Venice, Italy (d. 1542)
Lucrezia Borgia (1480-1519)
Apr 18 Italian noblewoman, daughter of Pope Alexander VI, born in Subiaco, Lazio, Papal States
