- Jan 12 Count Henry III of Nassau-Breda, Stadholder of Holland and Zeeland 1515-1521 (d. 1538)
Babur (1483-1530)
Feb 14 Timurid founder and 1st Emperor of the Mughal dynasty in the Indian Subcontinent (1526-30), born in Andijan, Timurid Empire (present-day Uzbekistan)
Raphael (1483-1520)
Apr 6 Italian painter and master builder (Sistine Madonna, School of Athens) [Julian calendar date], born in Urbino, Duchy of Urbino
- Oct 16 Gasparo Contarini, Italian diplomat and cardinal (d. 1542)
Martin Luther (1483-1546)
Nov 10 German theologian and key figure in the Protestant Reformation, born in Eisleben, Saxony, Holy Roman Empire
- Dec 3 Nicolaus von Amsdorf, German reformation theologist, born in Torgau, Saxony (d. 1565)