- Apr 15 Mimar Sinan, Ottoman architect and civil engineer for Sultans Suleiman the Magnificent, Selim II, and Murad III, born in Ağırnas, Karaman Eyalet, Ottoman Empire (d. 1588)
- Jun 4 Antoine, Duke of Lorraine, born in Bar-le-Duc, France (d. 1544)
- Jul 2 Thomas Cranmer, England reformer, Archbishop of Canterbury (1533-55), martyr, born in Aslockton, England (d. 1556)
- Aug 10 Jacob Sturm von Sturmeck, German statesman and reformer (d. 1553)
- Nov 28 Margaret Tudor, Queen consort of Scots as wife of James IV of Scotland (1503-13), born in Westminster Palace, London (d. 1541)