- Mar 6 Luigi Alamanni, Italian poet (Opere Toscane, La Coltivazione), born in Florence (d. 1556)
- Mar 8 John of God, Portuguese-born friar and saint, founder of the Hospitaller Order of St. John of God, born in Montemor-o-Novo, Évora, Portugal (d. 1550)
- Apr 16 Petrus Apianus [Peter Apian], German mathematician, astronomer and cartographer, born in Leisnig, Saxony (d. 1552)
- Aug 1 Jan van Scorel, Dutch painter and architect, born in Schoorl, Netherlands (d. 1562)
- Nov 21 John Bale, English bishop and anti-catholic playwright (Kynge Johan), born in Cove, Suffolk, England (d. 1563)
- Dec 5 Nicolas Cleynaerts, Flemish grammarian, born in Diest, Belgium (d. 1542)