- Apr 9 John, Cardinal of Lorraine, French churchman, born in Bar-le-Duc, Lorraine (d. 1550)
- Nov 15 Eleanor of Austria, Queen of Portugal and France, born in Leuven, Belgium (d. 1558)
- Dec 19 Andreas Osiander, German Protestant Reformation theologist, born in Gunzenhausen, Ansbach (d. 1552)