- Feb 2 René de Birague, French cardinal and chancellor (d. 1583)
- Feb 11 Juliana van Stolberg, engraver of Nassau
- Apr 7 Francis Xavier, saint/Jesuit missionary to India, Malaya, & Japan
- Apr 13 Peter Faber, French Jesuit theologian (co-founder of Society of Jesus), born in Villaret, Duchy of Savoy Holy Roman Empire (d. 1546)
- Jul 1 Louis II, King of Hungary and Bohemia (1516-26), born in Buda, Kingdom of Hungary (d. 1526)