- Feb 11 Gregory XIV [Niccolo Sfondrati], Italian Roman Catholic Pope (1590-91), born in Somma Lombardo, Duchy of Milan (d. 1591)
- May 31 Alessandro Allori, Italian painter and carpet designer, born in Florence, Italy (d. 1607)
- Jun 2 Leo XI [Alessandro Ottaviano de' Medici], Italian Pope in 1605 who had the shortest reign as pope in history, born in Florence (d. 1605)
- Jun 24 Joanna of Austria, Princess of Portugal, born in Madrid (d. 1573)
- Jul 22 Katarina Stenbock, wife of Gustav I of Sweden (d. 1621)
- Aug 21 Shimazu Yoshihiro, Japanese samurai and warlord, born in Kagoshima, Japan (d. 1619)
- Sep 6 Emanuel van Meteren, Flemish merchant and historian, born in Antwerp (d. 1612)
- Oct 16 Niwa Nagahide, Japanese warlord (d. 1585)