- Jan 7 Sebastian de Covarrubias Horozco, Spanish lexicographer (Treasury of Castilian or Spanish Language) (d. 1613)
- Feb 27 Franciscus Raphelengius, Flemish book publisher (1st Arabic-Latin dictionary), born in Lannoy (d. 1587)
- Mar 25 Christopher Clavius, German mathematician (d. 1612)
- Apr 17 Tobias Stimmer, Swiss painter (Strasbourg astronomical clock), born in Schaffhausen, Switzerland (d. 1584)
- Jun 13 Jost Amman, Swiss cartoonist, graphic artist and illustrator, born in Zürich, Switzerland (d. 1591)
- Nov 1 Pierre Pithou, French lawyer and scholar (Les Libertés de l’église gallicane), born in Troyes, France (d. 1596)
- Dec 5 Fausto Paolo Sozzini, Italian theologian and founder of Socinianism, born in Siena, Holy Roman Empire (d. 1604)