- Jan 26 Florent Chrestien, French writer (d. 1596)
- Mar 25 Francesco I de' Medici, Grand Duke of Tuscany (d. 1587)
- Apr 8 Michele Mercati, Italian physician and gardener, born in Rome, Italy (d. 1593)
- Oct 31 Hendrik van Kinschot, Dutch lawyer
- Nov 9 Menso Alting, Dutch reformed vicar and theologist, born in Eelde, Netherlands (d. 1612)