- Mar 11 Henric Laurenszoon Spieghel, Dutch Renaissance writer and poet (Hertspiegel), born in Amsterdam (d. 1612)
- Jul 30 Ferdinando I de' Medici, Grand Duke of Tuscany, born in Florence (d. 1609)
- Sep 1 Charles Philip of Croij, marquis of Havre/earl of Fontenoy, etc
- Oct 1 Anne of Saint Bartholomew, Flemish Roman Catholic nun, born in Almendral de la Cañada, Old Castile, Crown of Castile (d. 1626)
- Nov 2 Anna of Austria, fourth wife of Philip II of Spain, born in Cigales, Spain (d. 1580)
- Nov 5 Philippe de Mornay (or Philippe Du-Plessis-Mornay), French writer, born in Buhy, France (d. 1623)
- Dec 1 Johan van der Veeken, Dutch merchant, richest shipowner and banker in Rotterdam, born in Mechelen (d. 1616)