- Jan 5 Xu Xiake, Chinese geographer, born in Jiangsu, China (d. 1641)
- Jan 6 Gaspar de Guzman, Count of Olivares, Premier of Spain (1621-43), born in Rome, Italy (d. 1645)
- Jan 8 Johannes Fabricius, Danish astronomer (discovered sunspots), born in East Frisia, Germany (d. 1616)
- Jan 16 Alexander Adriaenssen, Flemish painter known for his still lifes of fish and game pieces, born in Antwerp (d. 1661)
- May 8 Victor Amadeus I, Duke of Savoy (1630-37), born in Turin, Piedmont, Savoy (d. 1637)
- Aug 18 1st English child born in New World (Virginia Dare)
- Nov 16 Joost van den Vondel, Dutch poet and dramatist (Jephtha), born in Cologne, Germany (d. 1679)
- Dec 25 Margarita of Austria, queen of Philip III of Spain (d. 1611)