- Jan 10 Joshua Barnes, English scholar, born in London, United Kingdom (d. 1712)
- Jan 20 Michiel de Swaen, South Netherland physician/poet
- Jan 22 Richard Blackmore, English physician and writer (d. 1729)
- Mar 16 Andreas Acoluthus, German orientalist (d. 1704)
- May 4 Kangxi Emperor of China, 4th Emperor of the Qing Dynasty, born in Jingren Palace, Forbidden City, Beijing, Qing dynasty, China (d. 1722)
- May 11 Cornelis van Alkemade, Dutch historian
- Jul 9 Emperor Reigen, 112th Emperor of Japan, born in Kyoto, Japan (d. 1732)
- Jul 31 Jacob Hop, Dutch politician and diplomat
- Aug 10 Bernard Nieuwentyt, Dutch physician/theologist
- Dec 27 Jacob Bernoulli, Swiss mathematician known for his contributions to calculus, born in Basel, Switzerland (d. 1705)