Events in History
- Jan 4 -6] 1st Altenburger sermon (Luther & Karl von Miltitz)
Event of Interest
Feb 18 Hernán Cortés leaves Cuba for the Yucatan Peninsula, Mexico with 11 ships and 500 men

Hernán Cortés
- May 9 Austrian adel and burgerij in uprising against central government
The Protestant Reformation
Jul 16 Public debate between Martin Luther and theologian Johann Eck at Pleissenburg Castle in Liepzig, during which Luther denies the divine right of the Pope
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- Jul 25 San Cristobal de la Habana forms in Cuba
Event of Interest
Jul 26 Francisco Pizarro receives royal charter for the west coast of South America

Francisco Pizarro
- Aug 15 Panama City founded by Spanish conquistador Pedro Arias Dávila
- Sep 2 1st Battle of Tehuacingo, San Salvador vs Mexico
- Sep 5 Second Battle of Tehuacingo, Mexico: Hernán Cortés vs Tlascala Aztecs
Historic Expedition
Sep 20 Spanish expedition led by Portuguese navigator Ferdinand Magellan sets off on the 1st successful circumnavigation of the globe (Magellan killed on route)

Ferdinand Magellan
Meeting of Interest
Nov 8 1st meeting of Aztec Emperor Moctezuma II and Spanish Conquistador Hernán Cortés in Tenochtitlan, Mexico

Moctezuma II

Hernán Cortés
- Nov 16 City of Havana moved to its current location to avoid mosquito infestations
Birthdays in History
- Jan 18 Isabella Jagiełło, Queen consort and regent of Hungary, born in Kraków, Poland (d. 1559)
- Feb 5 René of Châlon, (d. 1544)
- Feb 15 Pedro Menéndez de Avilés, Spanish admiral and explorer who founded St. Augustine, Florida, born in Avilés, Spain (d. 1574)
- Feb 16 Gaspard de Coligny, Huguenot leader/French admiral
- Feb 17 Francis, Duke of Guise, French soldier and politician (d. 1563)
- Apr 13 Catherine de' Medici, Italian born Queen consort to Henry II of France and later regent to her sons, born in Florence (d. 1589)
- May 27 Girolamo Mei, Italian historian and editor of Greek texts, born in Florence (d. 1594)
- Jun 6 Andrea Cesalpino, Italian philosopher, physician and botanist, born in Arezzo, Italy (d. 1603)
- Jun 12 Cosimo I de Medici, Grand Duke of Tuscany and art patron of Florence, born in Florence, Italy (d. 1574)
- Jun 24 Theodore Beza, French Reformed Protestant theologian, born in Vezelay, Burgundy, Kingdom of France (d. 1605)
- Jul 20 Pope Innocent IX [Giovanni Antonio Facchinetti], 230th Catholic pope (1591), born in Bologna, Papal States (d. 1591)
Deaths in History
Leonardo da Vinci
May 2 Leonardo da Vinci, Italian painter, sculptor, scientist and visionary, dies at 67

Leonardo da Vinci
- May 4 Lorenzo II de' Medici, Duke of Urbino, dies at 26
- Jun 24 Lucrezia Borgia, Italian noblewoman, daughter of Pope Alexander VI, dies at 39
- Aug 11 Johann Tetzel, Dominican monk, dies at about 79
- Aug 23 Philibert Berthelier, Swiss patriot
- Sep 10 John Colet, English churchman and educator
- Sep 21 Hans Backofen/Backoffen, German sculptor, dies at about 49
- Nov 30 Michael Wolgemut, German painter (Weltchronik), dies at about 85