- Feb 18 Duke of Clarence, privately executed and reputedly drowned in a butt of Malmsey wine
- Feb 22 Hendrik Herp (Herpius/Harphius), writer (Spieghel volcomenheit), dies
- Apr 26 Giuliano de' Medici, Italian co-ruler of Florence with his brother Lorenzo, murdered in the Pazzi Conspiracy in Duomo of Florence at 24
- Nov 19 Emperor Baeda Maryam of Ethiopia (b. 1448)