- Jan 11 Domenico Ghirlandaio, Italian artist (b. 1449)
- Jan 25 Ferdinand I, cruel king of Naples, dies
- Aug 11 Hans Memling [John Memlinc], Flemish painter (Passietaferelen), dies
- Sep 24 Poliziano, Italian humanist (b. 1454)
- Oct 22 Gian Galeazzo, Italian duke of Milan (1476-94), dies
- Nov 8 Melozzo da Forli, Italian painter, dies at about 56
- Nov 17 Giovanni Pico della Mirandola, Italian philosopher (b. 1463)
- Dec 20 Matteo Maria Boiardo, Italian poet