- Jan 11 Pedro González de Mendoza, Spanish cardinal and statesman, dies at 66
- Feb 10 William Stanley, Engl lord chamberlain, executed for conspiracy
- Feb 25 Djem Sultan, son of Turkish sultan Mehmed II, dies at 35
- May 31 Cecily Neville, mother of Edward IV of England and Richard III of England, dies at 80
- Sep 14 Elizabeth Tudor, English princess, the second daughter and fourth child of Henry VII of England and Elizabeth of York, dies at 3
- Oct 25 John II, the Perfect/Consummate, King of Portugal (1481-95), dies
- Nov 19 Alfonso II, king of Naples (1494-95), dies
- Dec 18 Alphonso II, King of Naples (1494-95), dies at 47