- Feb 1 Olivier de la Marche, Flemish soldier & poet, dies at 77
- Apr 2 Arthur, Prince of Wales, English crown prince, son of King Henry VII of England, 1st husband of Catherine of Aragon, dies from an unknown illness at 15
- Apr 15 Jan IV of Chalon-Arnay, prince of Orange and lord of Arlay, dies at 59
- May 6 James Tyrrell, alleged murderer of the Princes in the Tower (executed)
- Jul 11 Francisco de Bobadilla, Spanish soldier and second Governor of the Indies (1499-1502), dies during a storm at sea (born about 1450)
- Dec 23 Margaretha, English princess of Burgundy, dies at 57