- Feb 11 Henry, Duke of Cornwall, son of Henry VIII and Catherine of Aragon, dies at 7 weeks
- May 29 Nicolás de Ovando y Cáceres, Spanish Governor of the Indies (1501-09), dies at 50 or 51
- Aug 2 Andrew Barton, Scottish naval leader
- Sep 6 Ashikaga Yoshizumi, Japanese shogun (b. 1481)
- Nov 23 Princess Anne of York, 5th daughter of King Edward IV, dies at 36
- Nov 23 Mahmud Begada, Sultan of Gujarat (successfully captured Pavagadh and Junagadh forts in battles), dies at 66