- Jan 2 William Smyth, English bishop & statesman, dies at ~54
- Jan 9 Anna, Duchess of Brittany, queen of Charles VIII of France (b. 1477)
- Mar 11 Donato Bramante, Italian architect (b. 1444)
- Jun 25 Berta Jacobsdr [Suster Bertken], Dutch hermit, dies at 87
- Nov 28 Hartmann Skull, German physician/historian (Skull's Liederbuch), dies
- Dec 4 Richard Hunne, English "heretic", commits suicide(?)