- Jan 5 Marko Marulic/Marulus/Splichanin/Pechinich, Croatian poet, dies at 73
- Feb 20 Tecún Umán, last leader of the Quiché-Maya
- Apr 7 Philip of Burgundy, bishop of Utrecht, dies
- Apr 30 Pierre Terrail, seigneur de Bayard, French soldier (b. 1473)
- May 21 Thomas Howard 2nd duke of Norfolk, general/premier, dies at about 80
- May 23 Ismail I, Shah of Persia, converted Iran from Sunni to Shi'ah, dies at 36
- Jul 20 Claude of France, Duchess of Brittany and wife of Francis I of France, dies at 24
- Sep 18 Charlotte of Valois, Princess of France as second daughter of King Francis I and his wife Claude, dies at 7
- Oct 15 Joachim Patinir, Flemish landscape painter, dies at about 45
- Dec 10 Henry van Zutphen, Dutch Augustine/Luthern minister, burned to death
- Dec 11 Henry Van Zutphen, Dutch protestant martyr, burned at stake
- Dec 20 Thomas Linacre, English scholar and physician
Vasco da Gama
Dec 24 Vasco da Gama, Portuguese explorer and viceroy of Cochin, dies at about 55
