- Jan 6 Bernard van Orley, Flemish royal painter of Hungary, dies at about 52
- May 27 Margaret Pole, 8th Countess of Salisbury, daughter of George, Duke of Clarence, beheaded at 67 for treason in Tower of London by Henry VIII
Francisco Pizarro
Jun 26 Francisco Pizarro, Spanish conquistador who conquered the Inca Empire is assassinated in Lima by the son of his former companion and later antagonist, Diego Almagro the younger. Almagro is later caught and executed.
Paracelsus
Sep 24 Paracelsus, Swiss physician and alchemist (Zinc, Laudanum), dies at 47