Henry VIII
Jan 28 Henry VIII, King of England (1509-47), dies at 55
- Mar 30 Francis I of Valois, King of France (1515-47), dies at 52
Francis I of France
Mar 31 King Francis I of France (1515-47), dies complaining about the weight of the crown at 52
- Jun 21 Sebastiano del Piombo, Italian painter (b. 1485)
- Jul 20 Beatus Rhenanus [Beatus Birt], German humanist, classical scholar and friend of Erasmus, dies bequeathing his significant library to city of Sélestat, at 80
- Aug 7 Cajetanus van Thiene, Italian saint, dies
- Sep 10 Pierlugi Faraese, Italian son of Pope Paul III, murdered
- Oct 19 Pierino del Vaga, Italian painter, dies at about 46
Hernán Cortés
Dec 2 Hernán Cortés, Spanish conquistador (defeated the Aztec Empire and colonized large parts of Mexico), dies of pleurisy at 61 or 62
