- Feb 20 Nicholas Bacon, English politician (b. 1509)
- Jun 25 Hatano Hideharu, Japanese warlord and samurai (b. 1541)
- Jun 30 Mehmed Pasha Sokolović, Turkish Janissary
- Aug 5 Stanislaus Hosius, Polish Catholic cardinal (b. 1504)
- Oct 24 Albrecht V von Wittelsbach, duke of Bavaria, dies at 51
- Nov 15 Ferenc Dávid, Hungarian religious reformer (b. 1510)
- Nov 21 Thomas Gresham, English merchant and financier
- Dec 21 Vicente Masip, Spanish painter