Miguel de Cervantes
Apr 22 Miguel de Cervantes y Saavedra, Spanish author (Don Quixote), dies of a cirrhosis at 68
Miguel de Cervantes
William Shakespeare
Apr 23 William Shakespeare, English poet and playwright (b. 1564) (Julian calendar) dies aged 52
William Shakespeare
- Apr 23 El Inca Garcilaso de la Vega, Peruvian writer (b. 1539)
Tokugawa Ieyasu
Jun 1 Tokugawa Ieyasu, Japanese Shogun who founded the first Tokugawa Shogunate and united Japan, dies from natural causes
Tokugawa Ieyasu
- Jul 20 Hugh O'Neill, 3rd Earl of Tyrone, Irish soldier
- Jul 25 Andreas Libavius, German alchemist, dies
- Aug 7 Vincenzo Scamozzi, Italian architect (Procurazie Nuove, Venice), dies
- Aug 8 Cornelis Ketel, Dutch portrait painter/poet, buried at 68
- Aug 26 Johan van de Veeken, merchant/co-founder (VOC), dies at 66
- Oct 10 Maria van Nassau, countess of Buren, dies at 60
- Oct 17 John Pitts, Catholic scholar and writer. (b. 1560)
- Oct 23 Leonhard Hutter, German theologian (b. 1563)
- Nov 23 Richard Hakluyt, English writer (b. 1552)
- Dec 10 Diogo do Couto, Portuguese historian/archivist of Goa, dies at 74
- Dec 31 Jacques Le Maire, pirate/explorer (Lemaire Strait), dies at 31