- Jan 17 Diego Alvarez de Paz, Span missionary/writer (Peru), dies at about 59
- Feb 19 Roemer P Visscher, poet, buried in Amsterdam
- Mar 9 Aegidius Albertinus, German writer (Lucifer's Kingdom), dies at 59
- Mar 16 St. John Sarkander, Moravian priest, died of injuries caused by torturing
- May 6 Hayyim ben Joseph Vital, Palestinian-born Kabbalist (b. 1543)
- May 16 William Adams, English navigator and 1st ever Western Samurai, dies at 55
- May 31 Willem Louis, earl of Nassau-Dillenburg, dies at 59
- Jun 16 Carlo Saraceni [Carlo Veniziano], Italian painter (Judith), dies
- Jun 29 John Aerts, Flemish sculptor
- Aug 18 Wanli, Emperor of Ming Dynasty, dies at 56
- Sep 26 Taichang Emperor [Zhu Changluo], 14th Emperor of the Ming dynasty of China, dies at 38
- Oct 7 Stanisław Żółkiewski, Polish military leader (b. 1547)
- Nov 7 Hetman Stanisław Żólkiewski polish commander in the Battle of Ţuţora (1620) (b. 1547)
- Nov 9 Louise de Coligny, 4th wife of Willem of Orange, dies at 65
- Nov 13 Louise de Coligny, French 4th wife of Willem of Orange, dies at 65