- Jan 14 Paolo Sarpi, Italian church historian and politician, dies at 70
- Feb 8 Thomas Cecil, 1st Earl of Exeter, English politician, dies at 80
- Mar 19 Uesugi Kagekatsu, Japanese samurai and warlord (b. 1556)
- Jul 8 Gregory XV [Alessandro Ludovisi], bishop of Bologna/Pope, dies at 69
- Aug 6 Anne Hathaway, wife of English playwright William Shakespeare, dies aged 66 or 67
- Sep 10 John I Van de Velde the Elder, Dutch calligrapher (Mirror of Write-Konste), dies
- Oct 21 William Wade, English statesman and diplomat (b. 1546)
- Nov 9 William Camden, English historian (Brittania, Annales), dies at 72
- Nov 11 Philippe de Mornay (or Philippe Du-Plessis-Mornay), French writer, dies at 74