- Feb 10 Sebastian Stosskopf, Elizabethan painter, dies at 59
- Apr 2 Ferdinand III, King of Hungary & Bohemia and Holy Roman Emperor (1637-57), dies at 48
- Apr 2 Jean-Jacques Olier - French catholic priest, founder of the Society of Saint-Sulpice (b. 1608)
William Bradford
May 9 William Bradford, American governor (Plymouth Colony, Mass), dies at 57
William Bradford
- May 10 Gustaf Horn, Swedish soldier and politician, dies at 65
- May 16 Andrzej Bobola, Polish Jesuit missionary (b. 1591)
- Jun 3 William Harvey, English physician (discovered blood circulation), dies at 79
- Aug 6 Bohdan Khmelnytsky, Polish-Lithuanian noble
- Aug 7 Robert Blake, English admiral (Dover, Dungeness), dies at about 57
- Aug 19 Frans Snyders, Flemish painter of animals, dies at 77
- Aug 29 John Lilburne, English dissenter
- Sep 7 Arvid Wittenberg, Swedish count, field marshal and privy councilor (b. 1606)
- Sep 13 Jacob van Campen, painter/architect (Amsterdam Townhall), dies at 62
- Sep 26 Hadji Chalfa/Katib Tsjelebi, Turkish geographer, dies at 48
- Sep 28 Emilia Secunda Antwerpiana, 6th and youngest daughter of Willem of Orange, dies at 75