- Feb 17 Molière, [Jean Baptiste Poquelin], French playwright (The Misanthrope), dies of pulmonary tuberculosis at 51
- Mar 20 Augustyn Kordecki, Polish prior (b. 1603)
- Mar 28 Adam Pijnacker, Dutch landscape painter and etcher, buried at 51
- Apr 5 Francois Caron, admiral/governor (Formosa), drowns at about 72
- May 7 Johannes Teellinck, Dutch vicar, dies at about 58
- May 13 Jacob Aertsz Colom, Dutch publisher (Consolation of the Sea), dies at 73
Jeanne Mance
Jun 18 Jeanne Mance, French Canadian settler and founder of the first hospital in North America, dies at 66
Jeanne Mance
- Jun 24 John of Paffenrode, ruler of Ghussigny/poet, dies in battle
- Jun 25 Charles de Batz-Castelmore, Comte d'Artagnan, Captain of the Musketeers under Louis XIV of France (b. 1611)
- Aug 17 Regnier de Graaf, Dutch physician and anatomist, dies of possible suicide at 32
- Aug 21 Isaac Sweers, Dutch fleet admiral/Civil rights activist, dies at 51
- Aug 21 John de Love I, vice-admiral, dies in sea battle at about 54
- Oct 13 Kristoffer Gabel, Danish statesman (b. 1617)
- Oct 17 Thomas Clifford, English statesman (1st Baron Clifford of Chudleigh), dies at 43
- Nov 10 Michael Korybut Wisniowiecki, king of Poland (16..-73), dies
- Nov 14 Michael Wisniowieki, King of Poland, dies
- Nov 27 Anthonie Palamedesz, painter, dies at about 72
- Dec 15 Margaret Cavendish, English writer (b. 1623)
- Dec 28 Joan Blaeu, Dutch cartographer/publisher (Atlas Major), dies at 77
- Dec 31 Oliver St John, English statesman and judge