- Feb 12 Elkanah Settle, English poet and playwright, dies at 76
- Mar 7 Innocent XIII [Michelangiolo dei Conti], Pope (1721-24), dies at 68
- Mar 8 Enrico Giovanni Zuccalli, Swiss architect, dies at about 81
- May 3 John Leverett the Younger, American President of Harvard, dies at 61
- May 18 Johann K Amman, Swiss-Dutch doctor for deaf-mutes, dies at 54
- Jun 15 Henry Sacheverell, English churchman and politician (b. 1674)
- Oct 2 François-Timoléon de Choisy, French writer (Quatre dialogues sur l'immortalité de l'âme), dies at on his 80th birthday
- Nov 11 Joseph Blake, alias "Blueskin", a highwayman known for attacking "Thief-Taker General" (and thief) Jonathan Wild at the Old Bailey, is hanged in London. (b. c. 1700)
- Nov 16 Jack Sheppard, English robber, hanged
- Nov 18 Bartolomeu de Gusmão, Portuguese naturalist (b. 1685)