- Mar 3 William Stukeley, English physician and archaeologist (pioneered investigation of Stonehenge and Avebury), dies at 77
- Apr 5 Edward Young, English poet (Love of Fame), dies at 81
Maria Louise van Hessen-Kassel
Apr 9 Maria Louise van Hessen-Kassel, princess of Orange-Nassau, dies at 77
Maria Louise van Hessen-Kassel
- Apr 15 Mikhail Lomonosov, Russian scholar & poet, dies at 53
- Apr 20 Abigail Williams, American accuser in the Salem witch trials (b. 1674)
- May 17 Alexis Clairaut, French mathematician (Clairaut's theorem), dies at 52
- Jul 15 Charles-André Van Loo, French Rococo painter, dies at 60
- Aug 18 Francis I, Holy Roman Emperor (1745-65) dies at 56
- Aug 19 Axel Fredrik Cronstedt, Swedish Chemist who discovered nickel and tungsten, dies at 42
- Sep 2 Henry Bouquet, Swiss-born British army officer (b. 1719)
- Sep 10 Jacob Gilles, GRand Pensionary of Holland, dies at about 74
- Oct 10 Lionel Sackville, 1st Duke of Dorset, Lord Lieutenant of Ireland, dies at 77
- Oct 20 William Augustus, Duke of Cumberland, English supreme commander, dies at 44
- Oct 21 Giovanni Paolo Pannini, Italian painter and architect, dies at 73
- Oct 31 Duke of Cumberland, English politician/uncle of George III, dies
- Nov 30 George Glas, British merchant and adventurer (b. 1725)
- Dec 16 Peter Frederick Haldimand, Swiss military officer and surveyor
- Dec 25 Václav Prokop Diviš, Czech theologian and natural scientist, dies at 67