- Jan 10 Charles Cressent, French court furniture maker, dies at 82
- Feb 1 Sir Robert Rich, 4th Baronet, British cavalry officer (b. 1685)
- Feb 2 Robert Smith, English mathematician (b. 1689)
- Feb 8 George Dance the Elder, English architect (b. 1695)
- Feb 17 Arthur Onslow, English politician (b. 1691)
- Mar 1 Hermann Samuel Reimarus, German philosopher and writer (b. 1694)
- Mar 18 Lawrence Sterne, writer (Sentimental Journey France & Italy), dies
- Mar 21 Jan Jacob Mauricius, Dutch governor-general of Suriname (1742-51), dies at 75
- Apr 19 Filippo della Valle, Italian sculptor, dies at about 70
- Apr 19 Giovanni Antonio Canal [Canaletto], Italian painter and printmaker (Rialto), dies at 70
- Apr 29 Georg Brandt, Swedish chemist and minerologist (b. 1694)
- May 16 Cornelis Writer, fleet supervisor, dies at about 81
- May 27 Johann M Fleischmann, German/Dutch stamp/letter designer, dies
- Jun 8 Johann J Winckelmann, German archaeologist, dies at 50
- Jun 15 James Short, Scottish mathematician and optician (b. 1710)
- Jun 19 Benjamin Tasker, Governor of Maryland (b. 1690)
- Jul 4 Willem van Hairs, Fries nobleman and poet (Suicide), dies at 58
- Jul 24 Nathanial Lardner, English theologian (b. 1684)
- Aug 17 Vasily Kirillovich Trediakovsky, Russian poet (b. 1703)
- Sep 2 Antoine Deparcieux, French mathematician (b. 1703)
- Oct 1 Robert Simson, Scotland mathematician, dies at 80
- Nov 4 Johan Lulofs, Dutch physicist, philosopher and astronomer, dies at 57
Thomas Pelham-Holles
Nov 17 Thomas Pelham-Holles, 1st Duke of Newcastle, British Prime Minister (Whig: 1757-62), dies at 75
Thomas Pelham-Holles