- Jan 14 Franz Innocenz Joseph Kobell, German landscape painter, dies at 72
- Feb 5 Ali Paşa Tepelenë, known as 'The Lion of Janina", Ottoman Albanian ruler, Pasha of Yanina (1788-1822), dies aged somewhere between 78-82
- Feb 10 Albert Casimir, Duke of Teschen and Governor of the Austrian Netherlands, dies at 83
- Feb 24 Thomas Coutts, Anglo-Scottish banker (Coutts & Co.), dies at 86
- Mar 1 Jack Jouett, American politician & patriot (warn Thomas Jefferson of British attack), dies at 67
- Apr 3 Friedrich Justin Bertuch, German publisher and patron, dies at 74
- May 8 John Stark, American military officer (Battle of Bennington), dies at 93
- May 17 Armand-Emmanuel, Duc de Richelieu, Prime Minister of France (1815-18, 1820-21), dies at 55
- Jul 2 Denmark Vesey, American carpenter and ex-slave who planned an unsuccessful slave revolt in Charleston, South Carolina, hanged with 5 others at Blake's Landing, Charleston, South Carolina at about 55
- Jul 8 Percy Bysshe Shelley, English romantic poet (Adonais; Prometheus Unbound), drowns at 29
- Aug 12 Robert Stewart, 2nd marguess of Londonderry, commits suicide, dies
William Herschel
Aug 25 William Herschel, German-British astronomer (discovered Uranus), dies at 83
- Oct 13 Antonio Canova, Italian Neoclassical sculptor (The Three Graces), dies at 64
- Oct 29 Dirk van Hogendorp, Dutch minister of War, dies at 61
- Nov 6 Hendrik van Stralen, Secretary of Interior of the Netherlands, dies at 71
- Nov 6 Claude-Louis Berthollet, French chemist, dies at 73
- Nov 19 Johann Georg Tralles, German mathematician and physicist (b. 1763)