- Jan 5 Major George Johnston, Lieutenant-Governor of New South Wales (b. 1764)
- Jan 17 Zacharius Werner, German playwright, dies at 36
- Jan 21 Cayetano José Rodríguez, Argentine cleric, journalist and poet (b. 1761)
- Jan 26 Edward Jenner, English physician, father of immunology, pioneered smallpox vaccinations, dies at 73
- Feb 7 Ann Radcliffe (Ward), English poet/author of horror novels, dies at 58
- Feb 16 Pierre-Paul Prud'hon, French Romantic painter and draughtsman - allegorical paintings and portraits, dies at 64
- Mar 14 Charles François Dumouriez, French general (b. 1739)
- Mar 24 Cornelis van Foreest, Dutch politician, Mayor of Alkmaar, dies at 66
- Apr 7 Jacques-Alexandre-César Charles, French inventor and balloonist who (with Nicholas Robert) was the first to take flight in a hydrogen balloon, dies at 76
- Apr 10 Karl Leonhard Reinhold, Austrian philosopher (elementary philosophy), dies at 65
- Jun 1 Louis Nicholas Davout, French fieldmarshal, dies at 53
- Aug 2 Lazare Carnot, French politician, engineer and mathematician known as the Organizer of Victory in the French Revolutionary Wars, dies at 70
- Aug 3 Jacob Abraham de Mist, Dutch statesman, dies at 74
- Aug 20 Pius VII, [Luigi B Chiaramonti], Pope (1800-23), dies at 83
- Aug 20 Friedrich Arnold Brockhaus, German encyclopedia publisher, dies at 51
- Sep 11 David Ricardo, economist (b. 1772)
- Sep 17 Abraham L Breguet, French clock maker, dies at 76
- Sep 23 Matthew Baillie, Scottish Physician (first systematic study of pathology in 1793), dies at 61
- Oct 30 Edmund Cartwright, English inventor (power loom), dies at 80
- Dec 14 Vincenzo Cuoco, Italian historian (Naple revolution 1799), dies at 53