- Jan 5 Major George Johnston, Lieutenant-Governor of New South Wales (b. 1764)
- Jan 17 Zacharius Werner, German playwright, dies at 36
- Jan 21 Cayetano José Rodríguez, Argentine cleric, journalist and poet (b. 1761)
Edward Jenner
Jan 26 Edward Jenner, English physician, father of immunology, pioneered smallpox vaccinations, dies at 73
Edward Jenner
- Jan 27 Charles Hutton, English mathematician and surveyor, dies at 85
- Feb 7 Ann Radcliffe, English Gothic novelist (The Mysteries of Udolpho, The Romance of the Forest), dies at 58
- Feb 16 Pierre-Paul Prud'hon, French Romantic painter and draughtsman - allegorical paintings and portraits, dies at 64
- Feb 21 Charles Wolfe, Irish poet, dies at 31
- Mar 14 Charles François Dumouriez, French general (b. 1739)
- Mar 24 Cornelis van Foreest, Dutch politician, Mayor of Alkmaar, dies at 66
- Apr 7 Jacques-Alexandre-César Charles, French inventor and balloonist who (with Nicholas Robert) was the first to take flight in a hydrogen balloon, dies at 76
- Apr 10 Karl Leonhard Reinhold, Austrian philosopher (elementary philosophy), dies at 65
- Jun 1 Louis Nicholas Davout, French fieldmarshal, dies at 53
- Aug 2 Lazare Carnot, French politician, engineer and mathematician known as the Organizer of Victory in the French Revolutionary Wars, dies at 70
- Aug 3 Jacob Abraham de Mist, Dutch statesman, dies at 74
- Aug 20 Friedrich Arnold Brockhaus, German encyclopedia publisher, dies at 51
- Sep 11 David Ricardo, English economist (On the Principles of Political Economy and Taxation), dies at 51
- Sep 17 Abraham L Breguet, French clock maker, dies at 76
- Sep 23 Matthew Baillie, Scottish Physician (first systematic study of pathology in 1793), dies at 61
- Oct 30 Edmund Cartwright, English inventor (power loom), dies at 80
- Dec 14 Vincenzo Cuoco, Italian historian (Naples Revolution 1799), dies at 53