- Jan 3 Wilhelmus Kist, writer/director of Dutch (Official) Gazette, dies at 82
- Feb 11 J H Ferdinand Olivier, German painter, dies at 55
- Feb 13 Thomas Ainsworth, English/Dutch industrialist, dies at 45
- Feb 15 Sibrandus Stratingh, Dutch phyisican and chemist (electrical car), dies at 53
- Feb 25 Philip Pendleton Barbour, American politician and U.S. Supreme Court justice, dies at 57
- Mar 1 Claude Victor-Perrin, Duc de Belluno, French marshal, dies at 76
- Mar 16 Félix Savart, French surgeon and physicist (Law of Biot & Savart), dies at 49
William Henry Harrison
Apr 4 William Henry Harrison, 9th US President (Whig: March 4-April 4, 1841), dies of pneumonia and becomes 1st president to die in office
William Henry Harrison
- Apr 28 Peter Chanel, French priest & saint, dies at 37
- Apr 29 Aloysius Bertrand, French poet and playwright, dies of tuberculois at 34
- Apr 30 Peter Andreas Heiberg, Danish author and philologist, dies at 82
- May 3 Cornelis T Elout, Dutch minister of Finance/Navy/Colonies, dies at 74
- May 20 Joseph Blanco White, theological writert, dies
- May 23 Franz Xaver von Baader, German philosopher and theologist, dies at 76
- Jun 1 David Wilkie, British painter, dies at 55
- Jun 3 Nicolas Appert, French inventor of airtight food preservation (food canning, bouillon tablet), dies at 91
- Jul 27 Mikhail Lermontov, Russian poet and writer (Demon & other poems), dies at 26
- Aug 24 Theodore Edward Hook, English author (b. 1788)
- Sep 9 Augustin P de Candolle, Swiss botanist, dies at 63
George Childress
Oct 6 George Childress, American lawyer and statesman (author of Texas Declaration of Independence), commits suicide at 37
George Childress
- Oct 9 Karl Friedrich Schinkel, German architect, city planner and painter (Altes Museum, Neue Wache), dies at 60
- Oct 28 Johan August Arfwedson, Swedish chemist (b. 1792)
- Nov 1 Antoine Philippe Vischer, comte de Celles, Belgian-French politician, dies at 61
- Nov 13 Caroline of Baden, Queen of Bavaria, dies at 65
- Nov 14 Thomas Bruce, 7th earl of Elgin & Kincardine, British diplomat, dies at 75
- Nov 30 Charles Louis W J van Keverberg, Dutch government official, dies at 73