Portuguese Conquer Goa
Feb 17 Portuguese admiral Afonso de Albuquerque first conquers the city of Goa, entering it with little conflict
- May 30 Portuguese forces under Afonso de Albuquerque abandon Goa after its former ruler Yusuf Adil Shah, the Muslim King of Bijapur reconquers the city
- Jul 19 38 Jews are burned at stake in Berlin, Prussia
- Jul 25 Spanish conquest of Tripoli by Pedro Navarro for Aragon crown; over 3,000 killed and more than 5,000 inhabitants enslaved
- Sep 10 Bishop Frederik of Bathe recaptures Oldenzaal
- Dec 10 Muslim ruler of Goa, Yusuf Adil Shah and his Ottoman allies surrender to Portuguese forces led by Afonso de Albuquerque who puts the Muslim population to the sword