- Jan 19 Italian city Mirandola surrenders to the French
Event of Interest
Jul 25 Portuguese forces under Afonso de Albuquerque first assault the prosperous trading city of Malacca, Malay Peninsula
- Aug 10 Portuguese troops occupy parts of Malacca
- Aug 24 Afonso de Albuquerque of Portugal conquers Malacca, the capital of the Sultanate of Malacca.
- Sep 1 Conciliabulum of Pisa opens
- Oct 5 Eedgenootschap signs anti-French Saint League
- Nov 17 England, Spain and the Holy Roman Empire sign anti-French covenant The Treaty of Westminster