- Feb 5 French troops under Gaston de Foix rescue Bologna, which was under siege from a combined Papal-Spanish army
- Feb 16 Battle at Valeggio: French troops beat Venetianen
- Feb 19 French troops under Gaston de Foix occupy Brescia
Battle of Ravenna
Apr 11 Battle of Ravenna: French forces under Gaston de Foix defeat the Holy League in a major battle of the Italian Wars
- Aug 10 Battle of Saint-Mathieu (also called the Battle of Brest): an English fleet of 25 ships commanded by Sir Edward Howard and a Franco-Breton fleet of 22 ships commanded by René de Clermont.
The Protestant Reformation
Oct 21 Martin Luther joins the theological faculty of the University of Wittenberg.
Event of Interest
Nov 1 Michelangelo's paintings on ceiling of the Sistine Chapel in the Vatican first exhibited
- Dec 27 Spanish Crown issues the Laws of Burgos, governing the conduct of settlers with regards to native Indians in the New World