- Jan 4 1st Altenburger sermon in Saxony by Martin Luther & Karl von Miltitz
Historic Expedition
Feb 18 Hernán Cortés leaves Cuba for the Yucatan Peninsula, Mexico with 11 ships and 500 men
- May 9 Austrian adel and burgerij in uprising against central government
The Protestant Reformation
Jul 16 Public debate between Martin Luther and theologian Johann Eck at Pleissenburg Castle in Liepzig, during which Luther denies the divine right of the Pope
- Jul 25 San Cristobal de la Habana forms in Cuba
Event of Interest
Jul 26 Francisco Pizarro receives royal charter for the west coast of South America
- Aug 15 Panama City founded by Spanish conquistador Pedro Arias Dávila
- Sep 2 1st Battle of Tehuacingo, San Salvador vs Mexico
- Sep 5 Second Battle of Tehuacingo, Mexico: Hernán Cortés vs Tlascala Aztecs
Historic Expedition
Sep 20 Spanish expedition led by Portuguese navigator Ferdinand Magellan sets off on the 1st successful circumnavigation of the globe (Magellan killed on route)
Meeting of Interest
Nov 8 1st meeting of Aztec Emperor Moctezuma II and Spanish Conquistador Hernán Cortés in Tenochtitlan, Mexico
- Nov 16 City of Havana moved to its current location to avoid mosquito infestations